| Description | FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival. |
| In vivo | FR054的作用是通过PGM3抑制而非其他非靶向效应实现的。FR054（0.5-1 mM, 24-48小时）在乳腺癌细胞中引起早期的增殖停滞，随后显著增加细胞死亡，并诱导凋亡。FR054（250μM, 24小时）处理在MDA-MB-231细胞中有效影响N-和O-糖基化水平。FR054诱导内质网应激和依赖ROS的凋亡性细胞死亡[1]。 |
| molecular weight | 329.3 |
| Molecular formula | C14H19NO8 |
| CAS | 35954-65-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 75 mg/mL (227.76 mM) |
| References | 1. Francesca Ricciardiello, et al.Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis.Cell Death Dis. 2018 Mar 7;9(3):377. |