| Description | FR-168888, a new Na+/H+ exchange inhibitor, can protect the heart from arrhythmia and myocardial cell death in ischemic and reperfused situations. |
| Synonyms | FR-168888, FR-168888 Free Base, FR168888, FR 168888 |
| molecular weight | 354.38 |
| Molecular formula | C14H18N4O5S |
| CAS | 168620-46-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Zhu BM, Miyamoto S, Kamiya K, Komori S, Hashimoto K. Inhibitory effects of pre-ischemic and post-ischemic treatment with FR 168888, a Na+/H+ exchange inhibitor, on reperfusion-induced ventricular arrhythmias in anesthetized rat. Jpn J Pharmacol. 2002 Jan;88(1):93-9. PubMed PMID: 11855683. 2. Suzuki T, Yamaya M, Sekizawa K, Hosoda M, Yamada N, Ishizuka S, Nakayama K, Yanai M, Numazaki Y, Sasaki H. Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1. Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1115-27. PubMed PMID: 11350790. 3. Ohara F, Sugimoto T, Yamamoto N, Ohkubo K, Ozaki T, Maeda K, Seki J, Goto T. Protective effect of FR168888, a new Na+/H+ exchange inhibitor, on ischemia and reperfusion-induced arrhythmia and myocardial infarction in rats: in comparison with other cardioprotective compounds. Jpn J Pharmacol. 1999 Aug;80(4):295-302. PubMed PMID: 10496329. |