| Description | FPR Agonist 43 is a dual agonist of formyl peptide receptor 1 and formyl peptide receptor 2 (FPR2)/ALX. |
| In vitro | FPR Agonist 43 (10-5-107 nM) 在过表达FPR2/ALX的CHO细胞中通过cAMP测定表现出高活性。FPR Agonist 43 在GTPγ结合测定中也显示活性（IC50=207±51 nM）[1]。在人类中性粒细胞以及可能的鼠类细胞中，FPR1是FPR Agonist 43的首选受体[2]。 |
| molecular weight | 384.86 |
| Molecular formula | C20H21ClN4O2 |
| CAS | 903895-98-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 34.2 mg/mL (88.9 mM), Sonication is recommended. |
| References | 1. Planagumà A, et al. Lack of activity of 15-epi-lipoxin A₄ on FPR2/ALX and CysLT1 receptors in interleukin-8-driven human neutrophil function. Clin Exp Immunol. 2013 Aug;173(2):298-309. 2. Forsman H, et al. What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4? Scand J Immunol. 2011 Sep;74(3):227-234. |