| Description | Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM). |
| In vitro | Foliglurax is a highly selective and potent mGlu4 receptor PAM. It has a marked brain-penetrance feature, which might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders [2]. |
| Target activity | mGlu4:79 nM （EC50） |
| Synonyms | PXT002331 |
| molecular weight | 421.51 |
| Molecular formula | C23H23N3O3S |
| CAS | 1883329-51-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5.2 mg/mL (12.34 mM), Sonication and heating are recommended. |
| References | 1. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. 2. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423. |