| Description | Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM. |
| In vitro | Foliglurax, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders.a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature. |
| Target activity | mGlu4:79 nM （EC50） |
| Synonyms | PXT002331 (monohydrochloride) |
| molecular weight | 457.97 |
| Molecular formula | C23H24ClN3O3S |
| CAS | 2133294-96-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 5 mg/mL (10.92 mM), Sonication is recommended. |
| References | 1. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. 2. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423. |
Foliglurax monohydrochloride
CAS No.: 2133294-96-7
Foliglurax monohydrochlorideAntiparkinsonian effect.is a highly selective and potent, brain-penetrant metabotropic gluta
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