| Description | FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. |
| In vitro | FM26 ( 10 μM, 24h) significantly reduces IL-17a mRNA expression 27-fold in EL4 cells. |
| Target activity | RORγt:264 nM |
| molecular weight | 461.82 |
| Molecular formula | C22H15ClF3N3O3 |
| CAS | 2407981-35-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Meijer FA, et al.Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists.J Med Chem. 2020 Jan 9;63(1):241-259. |