| Description | Fluridone (EL-171) is a potent inhibitor of abscisic acid (ABA) synthesis, inhibits the expression of AchnFAR and TF genes, and reduces the formation of primary alcohol. Fluridone is often used as an aquatic herbicide to control invasive plants and is also used to control species such as hydra and Eurasian hydra. |
| In vitro | Fluridone对蓝藻Anacystis nidulans具有细胞毒性（LC50 = 0.125 µM）[1][4]。在暗处培养的T. aestivum 幼苗中，Fluridone（50和100 µM）会降低β-胡萝卜素水平，并诱导萜烯和萜烷的积累[2]。此外，当使用10 µM浓度时，Fluridone能降低湿润和脱水V. faba叶中植物激素脱落酸的水平[3]。 |
| In vivo | Fluridone 对多种无脊椎动物和鱼类表现出急性毒性（中位LC50分别为4.3和10.4 mg/L）。含Fluridone的配方已被用作水生除草剂。【1】【4】 |
| Target activity | Phytoene desaturase:0.03 μM(ki) |
| Synonyms | EL-171 |
| molecular weight | 329.32 |
| Molecular formula | C19H14F3NO |
| CAS | 59756-60-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 225.0 mg/mL (683.2 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Chamovitz D, et al. Molecular and biochemical characterization of herbicide-resistant mutants of cyanobacteria reveals that phytoene desaturation is a rate-limiting step in carotenoid biosynthesis. J Biol Chem. 1993;268(23):17348-17353. 2. Bartels P G, et al. Inhibition of carotenoid synthesis by fluridone and norflurazon. Weed Science, 1978;26(2): 198-203. 3. Popova L P, et al. Development and accumulation of ABA in fluridone‐treated and drought‐stressed Vicia faba plants under different light conditions. Physiologia Plantarum, 1996;98(4): 791-797. 4. Hamelink J L, et al. Toxicity of fluridone to aquatic invertebrates and fish[J]. Environmental Toxicology and Chemistry. An International Journal. 1986;5(1): 87-94. |