| In vivo |
(+)-Fluprostenol(s.c. to rats on day 18 of pregnancy) increased cervical creep, or softness, by the following day. Doses of (+)-Fluprostenol 100-fold larger were necessary to increase uterine contractions. (+)-Fluprostenol produced falls in serum progesterone concentrations, increases in 20 alpha-dihydroprogesterone concentrations, no changes in oestradiol or relaxin concentrations and a reduction in the ovarian human chorionic gonadotrophin binding capacity in vitro. (+)-Fluprostenol was less potent in inducing cervical softness when administered per vaginam, and a dose which produced softening in pregnant rats was ineffective in ovariectomized steroid-maintained pregnant or pro-oestrous rats[3]. |
| References |
1. Baryla M, Kaczynski P, Goryszewska E, Riley SC, Waclawik A. Prostaglandin F(2α) stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8/SVneo. Placenta. 2019 Feb;77:19-29. doi: 10.1016/j.placenta.2019.01.020. Epub 2019 Jan 24. PubMed PMID: 30827352. 2. Gao L, Gao R, Mao W, Liu B, Zhang S, Tahala D, Fu C, Shen Y, Wu J, Deng Y, Li Q, Cao J. PTGFR activation promotes the expression of PTGS-2 and growth factors via activation of the PKC signaling pathway in bovine endometrial epithelial cells. Anim Reprod Sci. 2018 Dec;199:30-39. doi:10.1016/j.anireprosci.2018.10.003. Epub 2018 Oct 14. PubMed PMID: 30340853. 3. Zhang S, Liu B, Gao L, Mao W, Fu C, Duritahala D, Zhang N, Zhang Y, Shen Y, Cao J. Prostaglandin F(2α)-PTGFR signalling activation, growth factor expression and cell proliferation in bovine endometrial explants. Reprod Fertil Dev. 2017 Oct;29(11):2195-2205. doi: 10.1071/RD16144. PubMed PMID: 28298246. 4. Ahmad SF, Akoum A, Horne AW. Selective modulation of the prostaglandin F2α pathway markedly impacts on endometriosis progression in a xenograft mouse model. Mol Hum Reprod. 2015 Dec;21(12):905-16. doi: 10.1093/molehr/gav056. Epub 2015 Oct 15. PubMed PMID: 26472819. |
