| Description | Fludalanine (MK641), an analogue of D-alanine, irreversiably inactivates racemase and also inhibits synthase. When used in combination with cycloserine, it has been found to be more active against a variety of non-mycobacterium organisms than fludalanine or cycloserine alone. |
| Synonyms | MK641, D-Alanine-2-d, 3-fluoro-, 3-Fluoro-D-(2-2H)alanine |
| molecular weight | 108.09 |
| Molecular formula | C3H5DFNO2 |
| CAS | 35523-45-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Musson DG, Maglietto SM, Hwang SS, Gravellese D, Bayne WF. Simultaneous quantification of cycloserine and its prodrug acetylacetonylcycloserine in plasma and urine by high-performance liquid chromatography using ultraviolet absorbance and fluorescence after post-column derivatization. J Chromatogr. 1987 Feb 20;414(1):121-9. PubMed PMID: 3571377. 2. Darland GK, Hajdu R, Kropp H, Kahan FM, Walker RW, Vandenheuvel WJ. Oxidative and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine. Drug Metab Dispos. 1986 Nov-Dec;14(6):668-73. PubMed PMID: 2877824. 3. Dickinson JM, Mitchison DA. Activity of the combination of fludalanine and cycloserine against mycobacteria in vitro. Tubercle. 1985 Jun;66(2):109-15. PubMed PMID: 4024268. 4. Musson DG, Maglietto SM, Bayne WF. Determination of the antibiotic fludalanine in plasma and urine by high-performance liquid chromatography using a packed-bed, post-column reactor with o-phthalaldehyde and 2-mercaptoethanol. J Chromatogr. 1985 Mar 22;338(2):357-67. PubMed PMID: 3998023. |