| Description | Floxacrine is drug candidate for chemoprophylaxis of malaria. |
| Synonyms | HOE-991, HOE 991, HOE991 |
| molecular weight | 407.77 |
| Molecular formula | C20H13ClF3NO3 |
| CAS | 53966-34-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Cross RM, Maignan JR, Mutka TS, Luong L, Sargent J, Kyle DE, Manetsch R. Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships. J Med Chem. 2011 Jul 14;54(13):4399-426. doi: 10.1021/jm200015a. Epub 2011 Jun 16. PubMed PMID: 21630666. 2. Milhous W. Development of new drugs for chemoprophylaxis of malaria. Bull Soc Pathol Exot. 2001 Jul;94(2 Pt 2):149-51. PubMed PMID: 16579068. 3. Milhous WK. Development of new drugs for chemoprophylaxis of malaria. Med Trop (Mars). 2001;61(1):48-50. Review. PubMed PMID: 11584654. 4. Dorn A, Scovill JP, Ellis WY, Matile H, Ridley RG, Vennerstrom JL. Short report: floxacrine analog WR 243251 inhibits hematin polymerization. Am J Trop Med Hyg. 2001 Jul;65(1):19-20. PubMed PMID: 11504401. |