| Description | FlAsH-EDT2 is a membrane-permeable fluorescent reagent that can label proteins. FlAsH-EDT2 can bind to CCXXCC motifs and nonspecific endogenous cysteine-rich proteins. FlAsH-EDT2 can only be used to label recombinant proteins that are expressed at very high levels. |
| Synonyms | FlAsH EDT2, FlAsH-EDT-2 |
| molecular weight | 664.5 |
| Molecular formula | C24H18As2O5S4 |
| CAS | 212118-77-9 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 18.0 mg/mL (27.1 mM) DMF: 13.5 mg/mL (20.3 mM) |
| References | 1. Stroffekova K, et al. The protein-labeling reagent FLASH-EDT2 binds not only to CCXXCC motifs but also non-specifically to endogenous cysteine-rich proteins. Pflugers Arch. 2001;442(6):859-866. 2. Adams SR, et al. Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins. Nat Protoc. 2008;3(9):1527-1534. 3. Piras L, et al. Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2. Biochem Biophys Res Commun. 2017;493(1):126-131. 4. Rotem R, et al. Direct quantification of cytosolic delivery of drug nanocarriers using FlAsH-EDT2. Nanomedicine. 2023;47:102626. |