| Description | FITC-Dextran (MW 4000) is a marker composed of fluorescein isothiocyanate conjugated to 4 kDa dextran, widely used in microcirculation and cell permeability studies. |
| Synonyms | 荧光素异硫氰酸酯-葡聚糖, FITC-Dextran (60842-46-8 MW 4000) |
| molecular weight | 4000 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 80 mg/mL DMSO: 10 mg/mL (2.5 mM), Sonication is recommended. |
| References | 1. Eriksson I, et al. Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells. Methods Mol Biol. 2017;1594:179-189. 2. Natarajan R, et al. Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability. Curr Protoc Neurosci. 2017 Apr 10;79:9.58.1-9.58.15. 3. Hoffmann A, et al. High and Low Molecular Weight Fluorescein Isothiocyanate (FITC)-Dextrans to Assess Blood-Brain Barrier Disruption: Technical Considerations. Transl Stroke Res. 2011 Mar;2(1):106-11. 4. Claire Gerkins，et al.Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran .J Vis Exp .2022 18 月 189;（）. DOI：10.3791/64710 |
| Citations | 1. Wang Y, Chen Y Y, Gao G B, et al.Polyphyllin D “Punctures” Hypertrophic Lysosomes to Reverse Drug Resistance of Hepatocellular Carcinoma by Targeting Acid Sphingomyelinase.Molecular Therapy.2023 2. Abate R, Bi Y, Song G, et al.Exogenous ethanol induces cell giantism accompanied by enhanced accumulation of lipid and carbohydrates in Chlorella sorokiniana.Journal of Applied Phycology.2024: 1-17. |