| Description | FITC-Dextran (MW 2,000,000) is a fluorescent dye-based compound that can be used for short cycle durations to outline blood vessels.FITC-Dextran (MW 2,000,000) is involved in the quantification of BBB leakage, and can be used in conjunction with a confocal microscope to visualize blood-brain-barrier leakage. |
| In vitro | FITC-Dextran (MW 2,000,000) 是一种异硫氰酸荧光素 (FITC) 葡聚糖荧光探针 (Ex=495 nm; Em=525 nm)，可作为一种标记物来揭示热休克引起的细胞损伤，并研究细胞凋亡的早期和晚期阶段。 |
| Synonyms | FITC-Dextran (MW 2000000) |
| molecular weight | N/A |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 40 mg/mL, Sonication is recommended. H2O: 15 mg/mL, Sonication is recommended. |
| References | 1. Natarajan R, et al. Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability. Curr Protoc Neurosci. 2017 Apr 10;79:9.58.1-9.58.15. 2. Eriksson I, et al. Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells. Methods Mol Biol. 2017;1594:179-189. 3. Yu W, et al. ACE2 contributes to the maintenance of mouse epithelial barrier function. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1276-1282. |