| Description | FGFR-IN-3 (compound 6) is a highly potent and orally active modulator of FGFR (fibroblast growth factor receptor). It has the ability to penetrate the blood-brain barrier (BBB). Additionally, FGFR-IN-3 exhibits significant neuroprotective properties. Therefore, it holds potential for research on neurodegenerative diseases [1]. |
| In vivo | FGFR-IN-3 (compound 6) is sufficiently lipophilic (logP = 2.2) to passively permeate across the blood-brain barrier, and further increase in molecular lipophilicity results in boosting MBI (mechanism-based inactivation) activity [1]. |
| molecular weight | 383.44 |
| Molecular formula | C18H27F2N5O2 |
| CAS | 2488762-63-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |