| Description | FFN 102 mesylate is a pH responsive fluorescent false neurotransmitter (FFN), a selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine and serotonin receptors. Inhibits dopamine uptake. Excitation maxima are 340 nm at pH 5 and 370 nm at pH 7.5. Emission maximum is 435 nm at both pH 5 and 7.5.FFN 102 mesylate is a Ph-responsive fluorescent pseudoneurotransmitter (FFN) that acts as a substrate for selective dopamine transporters (DAT) and VMAT2. |
| In vitro | FFN102的吸收光谱显示出pH依赖性：在较低pH值时，吸收峰向331 nm移动；而在较高pH值时，吸收峰向371 nm移动，分别对应于质子化和去质子化形态[1]。 |
| molecular weight | 335.76 |
| Molecular formula | C12H14ClNO6S |
| CAS | 1883548-92-2 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (134.02 mM), Sonication is recommended. H2O: 6.0 mg/mL (18.0 mM), Sonication is recommended. |
| References | 1. Rodriguez PC, et al. Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):870-5. 2. Lee M, et al. Development of pH-responsive fluorescent false neurotransmitters. J Am Chem Soc. 2010 Jul 7;132(26):8828-30. 3. Lee et al (2010) Development of pH-responsive fluorescent false neurotransmitters. J.Am.Chem.Soc. 132 8828 PMID: 20540519 |