| Description | Fendosal (HP-129) is a non-steroidal anti-inflammatory agent. It is 6.9 to 9.5 times more active than aspirin in the prophylactic and therapeutic adjuvant-induced polyarthritis models of chronic inflammation. |
| Synonyms | 芬度柳, HP 129, P 71-0129, P71-0129, P-71-0129, HP129, HP-129 |
| molecular weight | 381.42 |
| Molecular formula | C25H19NO3 |
| CAS | 53597-27-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22.5 mg/mL (58.99 mM) |
| References | 1. Wills RJ, Velagapudi RB, Puri SK, Yakatan GJ. The effect of food and antacid on the absorption of fendosal. Biopharm Drug Dispos. 1985 Jan-Mar;6(1):43-50. PubMed PMID: 3872688. 2. Lassman HB, Wilker JC, Anderson VB, Agnew MN, Allen RC, Novick WJ Jr. Fendosal (HP 129): a potent anti-inflammatory and analgesic compound. Agents Actions. 1978 Apr;8(3):209-17. PubMed PMID: 307337. 3. Desjardins PJ, Cooper SA, Ruderman CM, Gallegos LT, Reynolds DC, Kruger GO. The effects of fendosal, aspirin and placebo on postoperative dental pain. A dose-ranging and efficacy study. Pharmacotherapy. 1983 Jan-Feb;3(1):52-7. PubMed PMID: 6344034. 4. Warrander A, Metcalf R, Fromson JM. The disposition and metabolism of 5-(4,5-dihydro-2-phenylbenz[e]indol-3-yl)salicylic acid (fendosal) in the rat, mouse, rabbit, do, rhesus monkey, and man. Drug Metab Dispos. 1981 Mar-Apr;9(2):161-7. PubMed PMID: 6113117. |