| Description | FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.) |
| Target activity | FTO:60 nM (IC50) |
| molecular weight | 377.22 |
| Molecular formula | C18H14Cl2N2O3 |
| CAS | 2243736-35-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 25 mg/mL (66.27 mM) |
| References | 1. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia[J]. Science Foundation in China, 2019. |