PeptideDB

FAUC-113

CAS No.: 221470-50-4

FAUC-113 is an antagonist of Dopamine D4 receptor.
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Description FAUC-113 is an antagonist of Dopamine D4 receptor.
Synonyms FAUC113
molecular weight 326.82
Molecular formula C18H19ClN4
CAS 221470-50-4
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Lanig H, Utz W, Gmeiner P. Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine. J Med Chem. 2001 Apr 12;44(8):1151-7. PubMed PMID: 11312915. 2. Prante O, Hocke C, Löber S, Hübner H, Gmeiner P, Kuwert T. Tissue distribution of radioiodinated FAUC113: assessment of a pyrazolo(1,5-a) pyridine based dopamine D4 receptor radioligand candidate. Nuklearmedizin. 2006;45(1):41-8. PubMed PMID: 16493513. 3. Löber S, Aboul-Fadl T, Hübner H, Gmeiner P. Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy. Bioorg Med Chem Lett. 2002 Feb 25;12(4):633-6. PubMed PMID: 11844688. 4. Feng Z, Hou T, Li Y. Structure-based drug design for dopamine D3 receptor. Comb Chem High Throughput Screen. 2012 Dec;15(10):775-91. PubMed PMID: 22931309.