| Description | FATP1-IN-1 is a potent inhibitor of fatty acid transport protein 1 (FATP1). It effectively inhibits the activity of recombinant human or mouse acyl-CoA synthetase, which is essential for the function of FATP1. The inhibition is characterized by IC50 values of 0.046 μM for human FATP1 and 0.60 μM for mouse FATP1. |
| In vivo | FATP1-IN-1 (口服；10 mg/kg) 的治疗展现了其最大浓度（Cmax）为5.5 μg/mL，面积下曲线（AUC）为36 μg h/mL，达到最大浓度的时间（Tmax）为0.33小时，均超过小鼠半抑制浓度（IC50）0.22 μM。动物模型：小鼠血浆[1]。剂量：10 mg/kg。给药方式：口服。结果显示，最大浓度（Cmax）、面积下曲线（AUC）和达到最大浓度的时间（Tmax）分别为5.5 μg/mL、36 μg h/mL和0.33小时。 |
| Synonyms | FATP1-IN-1 |
| molecular weight | 375.46 |
| Molecular formula | C18H22FN5OS |
| CAS | 1431945-95-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 56.2 mg/mL (149.8 mM), Sonication is recommended. |
| References | 1. Matsufuji T, et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett. 2013;23(9):2560-2565. |