| Description | Exo1 is an inhibitor of the exocytic pathway |
| In vitro | Exo1是一种调节Golgi ARF1 GTP酶活性的化合物。它提供了一种独立干预Golgi活性的方式，因为Exo1影响了一部分被BFA阻断的膜事件，但似乎具有不同的蛋白质靶标（并且可能具有不同的副作用）。Exo1通过破坏Golgi结构，干扰了从内质网到Golgi装置的囊泡运输。Exo1以大约20 μM的IC50抑制胞吐。Exo1阻止新合成的蛋白质（如VSVGts-GFP、转铁蛋白和MHC类I[1]）获得对内切糖酶H的抵抗。 |
| molecular weight | 273.26 |
| Molecular formula | C15H12FNO3 |
| CAS | 75541-83-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 22.5 mg/mL (82.34 mM) |
| References | 1. Feng Y, et al. Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6469-74. |
| Citations | 1. Zhang X, Hong K, Sun Q, et al. Bioreducible, arginine-rich polydisulfide-based siRNA nanocomplexes with excellent tumor penetration for efficient gene silencing. Biomaterials Science. 2021, 9(15): 5275-5292. |