EVP-0015962 Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

CAS No.: 1447811-26-8

EVP-0015962, which is bioavailable orally, is a potent and selective gamma-secretase regulator in vitro and in vivo, det

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Description	EVP-0015962, which is bioavailable orally, is a potent and selective gamma-secretase regulator in vitro and in vivo, detectable in the brain.
molecular weight	480.83
Molecular formula	C22H19ClF6O3
CAS	1447811-26-8
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Rogers K, Felsenstein KM, Hrdlicka L, Tu Z, Albayya F, Lee W, Hopp S, Miller MJ, Spaulding D, Yang Z, Hodgdon H, Nolan S, Wen M, Costa D, Blain JF, Freeman E, De Strooper B, Vulsteke V, Scrocchi L, Zetterberg H, Portelius E, Hutter-Paier B, Havas D, Ahlijanian M, Flood D, Leventhal L, Shapiro G, Patzke H, Chesworth R, Koenig G. Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice. Mol Neurodegener. 2012 Dec 18;7:61. doi: 10.1186/1750-1326-7-61. PubMed PMID: 23249765; PubMed Central PMCID: PMC3573960.