| Description | Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 μg/ml. |
| Synonyms | 东革阿里提取物, Pasakbumin A |
| molecular weight | 408.4 |
| Molecular formula | C20H24O9 |
| CAS | 84633-29-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (122.43 mM) |
| References | 1. Hajjouli S, et al.Eurycomanone and eurycomanol from Eurycoma longifolia Jack as regulators of signaling pathways involved in proliferation, cell death and inflammation.Molecules. 2014 Sep 16;19(9):14649-66. 2. Pan Y, et al.Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro.J Nat Med. 2014 Apr;68(2):402-6. 3. Wong PF， et al.Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28.Phytomedicine. 2012 Jan 15;19(2):138-44. 4. Zakaria Y, et al.Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53.Cancer Cell Int. 2009 Jun 10;9:16. doi: 10.1186/1475-2867-9-16. |