| Description | Etimizol (Ethimizole) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). The positive effect of Etimizol on memory is related to its influence on the consolidation stage. |
| In vivo | 外源性施加5-10 mM/L的Etimizol（Ethymisole）对Coretus corneus孤立神经系统的巨神经元表现出特异性作用：动作电位持续时间显著延长，下降相的发展速度减慢，以及追踪后超极化幅度减小。在几个实验系列中，施用Etimizol（3 mg/kg）与学习开始的时间间隔变化在0.5至3小时之间。无论施药时间及生物强化方式，Etimizol（Ethymisole）均未促进大鼠的学习能力。在应用Etimizol（Ethymisole）的剂量分别为10或1 mg/loop后，Etimizol在环中的平均驻留时间分别为20.1分钟和7.6分钟，其平均标准偏差分别为3.1和0.8。 |
| Synonyms | Ethymisol, Ethimizole, Ethymisole |
| molecular weight | 210.23 |
| Molecular formula | C9H14N4O2 |
| CAS | 64-99-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: 33 mg/mL (156.97 mM) |
| References | 1. Borisova GIu. Effect of etimizol on instrumental learning in rats. Biull Eksp Biol Med. 1985 Jun;99(6):705-6. 2. Trnovec T, et al. Etimizol absorption from the small intestine in dogs: the dependence on dosage. Biull Eksp Biol Med. 1986 Dec;102(12):729-30. 3. Vislobokov AI, et al. Elektrophysiological parameters of mollusk neurons under the influence of etimizol. Fiziol Zh SSSR Im I M Sechenova. 1975 Jun;61(6):917-24. |