| Description | Ethylparaben (Ethyl parahydroxybenzoate) is a Standardized Chemical Allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. |
| In vitro | Ethylparaben 在体外显示出弱雌激素效应及弱抗雄性激素效应[2]。 |
| In vivo | 体内研究显示，ethylparaben 在未成熟和去卵巢的小鼠中显示出雌激素效应。对ethylparaben 对胎儿暴露的研究未发现雄性肛门至生殖器距离变化和胎儿睾酮生产变化，但基因表达水平的变化暗示了微妙的内分泌干扰效应。一项对年轻雄性大鼠的有限研究未发现不良影响，但观察到精子计数降低的趋势。ethylparaben 在鱼类中导致维托格宁诱导[2]。 |
| Synonyms | Ethyl 4-hydroxybenzoate, Ethyl parahydroxybenzoate, 羟苯乙酯, 尼泊金乙酯 |
| molecular weight | 166.17 |
| Molecular formula | C9H10O3 |
| CAS | 120-47-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 45 mg/mL (270.81 mM) Ethanol: 31 mg/mL (186.6 mM) |
| References | 1. Frederiksen H, et al. Toxicol Sci. 2008, 106(2):376-83. 2. Evaluation of tebuconazole, triclosan, methylparaben and ethylparaben according to the Danish proposal for criteria for endocrine disrupters, May 2012. |