Ethoxylated hydrogenated castor oil Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Ethoxylated hydrogenated castor oil is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o/w) emulsions.
In vivo	将近20%的Ethoxylated hydrogenated castor oil被用来乳化甘油单油酸酯(GMO)作为油进入水相。在Webster小鼠中，一次性口服5000 mg/kg的空白纳米乳剂，每天一次，连续14天，此纳米乳剂未产生有害效应，且对食物摄入无影响[1]。20%Ethoxylated hydrogenated castor oil（10 μl）被涂于小鼠的左耳，而右耳作为对照。观察小鼠6天内是否出现红斑发展，未观察到小鼠有任何刺激迹象[2]。通过尾静脉注射Ethoxylated hydrogenated castor oil（300、900及2700 mg/kg；4周）进行短期毒性测试。300和900 mg/kg的PEG-40 氢化蓖麻油剂量未表现出系统毒性。然而，2700 mg/kg剂量下，观察到轻微的共济失调，并且在男性中体重显著降低，在女性中略有降低[2]。
molecular weight	N/A
CAS	61788-85-0
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	H2O: 100 mg/mL
References	1. Heni Rachmawati, et al. The In Vitro-In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation. Sci Pharm. 2017 Mar 31;85(2):18. doi: 10.3390/scipharm85020018. 2. PEG-40 hydrogenated Castor Oil: Does It Benefit The Skin?

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