| Description | Estredox (E2 CDS) is a redox-based estradiol (E2) chemical delivery system.E2-CDS provides sustained and brain-selective delivery of estradiol. |
| In vivo | 卵巢切除小鼠以 300 μg/kg 体重的剂量通过尾静脉注射Estredox-CDS （30 μL），会触发卵巢切除小鼠的短暂抗抑郁样行为。[1]；单次静脉注射 Estredox-CDS （3 mg/kg） 导致 E2-Q+ 在三个不同的大脑区域持续存在。E2-Q+中雌二醇的持续和逐渐释放反映在血浆雌激素水平的时间过程中。在重复给药Estredox-CDS结束时（每天一次，0.3mg / kg，静脉注射，连续10天），我们发现血浆雌二醇水平急剧下降，然后逐渐下降。[3]；在睾丸切除的雄性大鼠中，Estredox 在单剂量 0.3 和 3.0 mg/kg iv 后，重新建立了长达 4 周的安装和内入。LH抑制作用分别持续到第7天和第28天。以0.01mg/kg iv的剂量重复给药10天后，第14天获得显着效果。[4] |
| Synonyms | E-2CDS, IDR 90104, E 2CDS, E2 CDS, IDR-90104, E-2-CDS |
| molecular weight | 393.52 |
| Molecular formula | C25H31NO3 |
| CAS | 103562-82-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Prokai-Tatrai K, et al. "All in the mind"? Brain-targeting chemical delivery system of 17β-estradiol (Estredox) produces significant uterotrophic side effect. Pharm Anal Acta. 2012;Suppl 7. 2. Patthy M, et al.Determination of estredox, a compound with sustained estradiol function, and its impurity profile by HPLC. Pharmazie. 2008 Mar;63(3):210-6. 3. Sziráki I, et al.Bodor N. Comparative evaluation of Estredox, a brain-targeted estradiol delivery system versus traditional estrogen replacement therapy. Pharmazie. 2006 Feb;61(2):140-3. 4. Tapfer MK, et al.New evidence for the selective, long-lasting central effects of the brain-targeted estradiol, Estredox. Pharmacol Biochem Behav. 2004 Mar;77(3):423-9. |