| Description | ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer. |
| In vitro | 在MCF-7细胞中，ErSO（1-1000纳摩尔）具有抑制细胞活力的功能，其IC50为20.3纳摩尔。ErSO（1微摩尔）能在TYS和TDG细胞中迅速杀死ERα阳性乳腺癌细胞，并在[1]中诱导快速杀死ERα阳性的MCF-7人乳腺癌细胞。 |
| In vivo | ErSO（10及40 mg/kg；口服）在14天内使所有五只小鼠的TYS-luciferase表达乳腺肿瘤量回退超过100000倍（至无法检测水平），并实现>10000倍的肿瘤量回退。在Nu/J小鼠中，ErSO（10或40 mg/kg；口服）在所有情况下消除肿瘤，减少率超过90%[1]。 |
| molecular weight | 453.33 |
| Molecular formula | C22H13F6NO3 |
| CAS | 2407860-35-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (220.6 mM), Sonication is recommended. |
| References | 1. Boudreau MW, et al. A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Sci Transl Med. 2021;13(603):eabf1383. |