| Description | Erinacine A is an anticancer compound that can be extracted from the monkey head mushroom and is capable of inducing cancer cell death through the production of reactive oxygen species (ROS).Erinacine A may exert its anticancer activity by participating in the modulation of signaling pathways.Erinacine A has anticancer, antitumor, and neuroprotective activities. |
| In vitro | Erinacine A (1-10 µM; 24小时) 处理 TSGH 9201 细胞后，增加了细胞毒性和活性氧 (ROS) 生成，并减少了细胞的侵袭性。使用 erinacine A 处理 TSGH 9201 细胞导致 caspases 的激活和 TRAIL 的表达。Erinacine A 诱导的细胞凋亡伴随着 FAK/AKT/p70S6K 和 PAK1 通路的持续磷酸化以及 ROS 的生成。此外，erinacine A 诱导的细胞凋亡和抗侵袭性质可能涉及 14-3-3 sigma 蛋白（1433S）和微管相关肿瘤抑制候选蛋白 2 (MTUS2) 的差异表达，与 FAK/AKT/p70S6K 和 PAK1 信号通路的激活。这些结果使我们推测，erinacine A 可能通过激活 FAK/AKT/p70S6K/PAK1 通路并上调蛋白 1433S 和 MTUS2，在 TSGH 9201 细胞中产生细胞凋亡级联反应，为 erinacine A 在人胃癌细胞中的抗癌效果提供了新的作用机制。[1] |
| molecular weight | 432.55 |
| Molecular formula | C25H36O6 |
| CAS | 156101-08-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kuo HC, et al. A Comparative Proteomic Analysis of Erinacine A's Inhibition of Gastric Cancer Cell Viability and Invasiveness. Cell Physiol Biochem. 2017;43(1):195-208. 2. Lee KC, et al. A proteomics approach to identifying novel protein targets involved in erinacine A-mediated inhibition of colorectal cancer cells' aggressiveness. J Cell Mol Med. 2017;21(3):588-599. |