| Description | Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis.Ergosta-7,22-dien-3-one has pro-inflammatory properties, it stimulates nitric oxide production, induces gene expression, and induces the production of TLRs, cytokines, chemokines, and cellular adhesion molecules. |
| In vitro | Ergosta-7,22-dien-3-one，来自墨西哥野生Ganoderma oerstedii菌株的分离物。研究表明，Ergosta-7,22-dien-3-one对HeLa或J774A.1细胞没有表现出任何细胞毒性作用，并能够刺激一氧化氮的产生，诱导基因表达，并在J774A.1细胞中诱导TLRs、细胞因子、趋化因子和细胞粘附分子的产生，这一发现是基于逆转录聚合酶链反应和酶联免疫吸附测定的结果。我们在这里报道了Ergosta-7,22-dien-3-one的一种新的促炎特性，鉴于其生物活性，应被视为可能的辅助性质。[1] |
| molecular weight | 396.65 |
| Molecular formula | C28H44O |
| CAS | 32507-77-0 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Ramos-Ligonio A, et al. In Vitro Expression of Toll-Like Receptors and Proinflammatory Molecules Induced by Ergosta- 7,22-Dien-3-One Isolated from a Wild Mexican Strain of Ganoderma oerstedii (Agaricomycetes). Int J Med Mushrooms. 2017;19(3):203-211. 2. Ko HH, et al. Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae. Phytochemistry. 2008;69(1):234-239. 3. Gao J, et al. Cytotoxic constituents of Lasiosphaera fenzlii on different cell lines and the synergistic effects with paclitaxel. Nat Prod Res. 2016;30(16):1862-1865. |