| Description | NSC-139021 (ERGi-USU) is a Rio2 kinase (RIOK2) inhibitor that inhibits ERG protein. |
| In vitro | ERGi-USU选择性地抑制ERG阳性癌细胞系的生长，对正常前列腺或内皮细胞以及ERG阴性肿瘤细胞系的影响微小。对于敏感细胞系，ERGi-USU抑制细胞生长的IC50范围在30 nM至400 nM[1]。 |
| Target activity | ERG (positive cancer cells):30 to 400 nM (IC50) |
| Synonyms | 1-(2-噻唑基偶氮)-2-萘酚 |
| molecular weight | 255.3 |
| Molecular formula | C13H9N3OS |
| CAS | 1147-56-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 62 mg/mL (242.85 mM) |
| References | 1. Mohamed A A , Xavier C P , Sukumar G , et al. Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth[J]. Cancer Research, 2018:canres.2949.2017. |