| Description | ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates. |
| In vitro | ERAP1-IN-1（50 μM）在细胞环境中展示出对ERAP1的特异性抑制效果。同时，ERAP1-IN-1能通过变构方式激活ERAP1对荧光和显色氨基酸底物的水解作用。 |
| molecular weight | 458.45 |
| Molecular formula | C20H21F3N2O5S |
| CAS | 865273-97-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 250 mg/mL (545.32 mM), Sonication is recommended. |
| References | 1. Maben Z, et al. Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. J Med Chem. 2019 Dec 30. |