| Description | ER176 is a novel PET radioligand utilized for the visualization of 18 kDa translocator protein (TSPO), a neuroinflammation biomarker, marking the advancement in imaging technology. |
| In vitro | ER176 shows homozygous high-affinity binders (HABs)/heterozygous mixed affinity binders (MABs) ratio for BP ND (specific-to-non-displaceable ratio of distribution volumes) of 1.2[1]. |
| molecular weight | 353.85 |
| Molecular formula | C20H20ClN3O |
| CAS | 1373887-29-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Masahiro Fujita, et al. Comparison of four 11 C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios. EJNMMI Res. 2017 Oct 16;7(1):84. 2. Jason C Mixdorf, et al. Alternative strategies for the synthesis of [ 11 C]ER176 for PET imaging of neuroinflammation. Appl Radiat Isot. 2021 Sep 17;178:109954. |