| Description | Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity that increases monocyte-endothelial adhesion through NF-κB signalling.Equilin similarly relaxes mesenteric arterial resistance by blocking Ca(2+) entry into smooth muscle. |
| In vitro | 在共轭马雌激素中，Equilin通过NF-κB信号传导途径增强单核细胞-内皮细胞的粘附作用[2]。 |
| Synonyms | 7-Dehydroestrone |
| molecular weight | 268.35 |
| Molecular formula | C18H20O2 |
| CAS | 474-86-2 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (298.12 mM), Sonication is recommended. |
| References | 1. David K, De Jongh SE. Some biological properties of equilin. Biochem J. 1935 Feb;29(2):371-7. 2. Ito F, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS One. 2019;14(1):e021146Published 2019 Jan 30. 3. Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147(2):211-220. |