| Description | Epifriedelanol (Epifriedelinol) suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts (HDFs) and HUVECs. Because of Epifriedelanol can reduce cellular senescence in human primary cells, it may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. |
| Synonyms | 表木栓醇, Epifriedelinol |
| molecular weight | 428.73 |
| Molecular formula | C30H52O |
| CAS | 16844-71-6 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 0.71 mg/mL(1.66 mM）, Sonication is recommended. |
| References | 1. Yang HH., et al. Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cells.Planta Med. 2011 Mar;77(5):441-9. 2. Kundu JK., et al. Antitumor activity of epifriedelanol from Vitis trifolia. Fitoterapia. 2000 Sep;71(5):577-9. 3. Jia LY., et al. A new cycloartane nortriterpenoid from stem and leaf of Quercus variabilis. J Asian Nat Prod Res. 2013 Sep;15(9):1050-4. 4. Cai J., et al. Potent protein tyrosine phosphatase 1B (PTP1B) inhibiting constituents from Anoectochilus chapaensis and molecular docking studies. Pharm Biol. 2015 Jul;53(7):1030-4. 5. Wang, Y. et al.: Spectrochim Acta A Mol Biomol. Spectrosc., 153, 645 (2016) |