| Description | Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). |
| In vivo | 在不同组织中,如肝、十二指肠、肾和肺中,Entacapone抑制茶酚-O-甲基转移酶（COMT）的活性。在PC12细胞中,Entacapone能够抑制α-syn和β-淀粉样蛋白（Aβ）聚集诱导的细胞外毒性。 |
| Target activity | COMT:151 nM |
| Synonyms | OR-611, 恩他卡朋 |
| molecular weight | 305.29 |
| Molecular formula | C14H15N3O5 |
| CAS | 130929-57-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (163.78 mM) Ethanol: 2 mg/mL (6.55 mM) |
| References | 1. De Santi C, et al. Eur J Clin Pharmacol, 1998, 54(3), 215-219. 2. Di Giovanni S, et al. J Biol Chem, 2010, 285(20), 14941-14954. 3. Jenner P, et al. Neurology, 2004, 62(1 Suppl 1), S47-55. 4. Hamaue N, et al. Brain Res, 2010, 1309, 110-115. |