| Description | Entacapone acid (AG 1290) is a selective and reversible inhibitor of catechol-O-methyltransferase(COMT). |
| Synonyms | AG1290, AG 1290, AG-1290, 恩他卡朋酸 |
| molecular weight | 250.16 |
| Molecular formula | C10H6N2O6 |
| CAS | 160391-70-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/ml (219.86 mM) |
| References | 1. Belal F, et al. Micellar HPLC-UV method for the simultaneous determination of levodopa, carbidopa and entacapone in pharmaceuticals and human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 22;1091:36-45. 2. Engelbrecht I, Petzer JP, Petzer A. Nitrocatechol Derivatives of Chalcone as Inhibitors of Monoamine Oxidase and Catechol-O-Methyltransferase. Cent Nerv Syst Agents Med Chem. 2018 Apr 26. 3. Grünig D, et al. Effect of the catechol-O-methyltransferase inhibitors tolcapone and entacapone on fatty acid metabolism in HepaRG cells. Toxicol Sci. 2018 Apr 23. 4. Ware BR, et al. Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling. Toxicol Sci. 2017 Jun 1;157(2):387-398. |