| Description | Enpp-1-IN-11 (compound 23) is a highly potent inhibitor of Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1), with a Ki value of 45 nM. It demonstrates excellent stability in human and mouse plasma and exhibits low clearance in both human and mouse liver microsomes. Enpp-1-IN-11 holds promise for anticancer research [1]. |
| In vivo | Enpp-1-IN-11 has low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma [1]. Pharmacokinetic Parameters of Enpp-1-IN-11 in female BALB/c mice [1]. PO (10 mg/kg) IV (1 mg/kg) T max (h) 1.2 C max (ng/mL) 33.10 1600.20 C 0 (ng/mL) 4546.51 T max (h) 0.50 0.08 AUC last (ng/mL·h) 29.47 404.40 AUC inf (ng/mL·h) 31.78 415.55 AUC extrap (%) 7.26 2.68 t 1/2 (h) 0.54 0.11 MRT last (h) 0.66 0.07 CL (mL/min/kg) 40.10 V SS (L/kg) 0.22 F (%) <1 |
| molecular weight | 345.38 |
| Molecular formula | C15H15N5O3S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |