| Description | ELOVL6-IN-1 is a potent, selective, and orally active inhibitor of ELOVL6. It exhibits dose-dependent inhibition of mouse ELOVL6 with an IC50 of 0.350 μM and functions as a noncompetitive inhibitor with respect to malonyl-CoA (Ki=994 nM) and palmitoyl-CoA [1]. |
| In vitro | ELOVL6-IN-1显示出良好的亲脂性，有能力通过被动扩散机制渗透细胞膜进入细胞内部[1]。 |
| In vivo | ELOVL6-IN-1（10 mg/kg；口服；0~2小时）在血浆和肝脏内显示出明显的药物暴露水平[1]。ELOVL6-IN-1（10及30 mg/kg；口服；0~2小时）有效降低了肝脂质的合成延长作用[1]。ELOVL6-IN-1（100 mg/kg；口服；2天）显著减少了肝脏中总脂肪酸的合成延长率[1]。 |
| molecular weight | 495.49 |
| Molecular formula | C27H24F3N3O3 |
| CAS | 712346-06-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |