| Description | ELOVL1-IN-2, a compound known as an inhibitor of the elongation of very long chain fatty acid 1 (ELOVL1) enzyme, exhibits a weak inhibitory effect on ELOVL1 (with an IC50 of 21 μM) and demonstrates moderate potency in a primary cellular assay conducted on HEK293 C26 cells (with an IC50 of 6.7 μM) [1]. |
| Target activity | ELOVL1:21 μM, HEK293 C26:6.7 μM |
| molecular weight | 294.32 |
| Molecular formula | C18H15FN2O |
| CAS | 2761063-79-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (203.86 mM), Sonication is recommended. |
| References | 1. Boyd MJ, et al. Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVLJ Med Chem. 2021 ; 64(24):17777-17794. |