| Description | Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides. |
| In vitro | Eledoisin在基础条件下增加了24.5±3.7%的记录值；同时存在CP99994时，此刺激显著（P<0.01）降低至13.1±1.9%。同一协议还用于评估Eledoisin刺激对0.1 μM SR48968或0.1 μM SB222200的敏感性。SR48968显著（P < 0.01）降低了Eledoisin的刺激效果，而SB222200无影响。Eledoisin的刺激效果由CP99994和SR48968（分别为NK1和NK2拮抗剂）减弱[1]。 |
| In vivo | 向大鼠注射Eledoisin（0.1-1 nmol/kg）会产生双相心血管反应，初期表现为系统性血压下降（8-15 mm Hg），随后血压上升（20-22 mm Hg）。 |
| Synonyms | Eledone peptide, 依来多辛 |
| molecular weight | 1188.4 |
| Molecular formula | C54H85N13O15S |
| CAS | 69-25-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 18.15 mg/mL (15.27 mM), Sonication and heating are recommended. |
| References | 1. Lippe C, et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides. 2004 Nov;25(11):1971-5. |