| Description | EGNHS (EGS crosslinker) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| In vitro | PROTACs通过连接器连接两种不同的配体；一个是E3泛素连接酶的配体，另一个是目标蛋白的配体。PROTACs利用细胞内的泛素-蛋白酶体系统，有选择性地降解目标蛋白[1]。 |
| Synonyms | EGS crosslinker |
| molecular weight | 456.36 |
| Molecular formula | C18H20N2O12 |
| CAS | 70539-42-3 |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 90.0 mg/mL (197.2 mM), Sonication is recommended. H2O: 3.8 mg/mL (8.2 mM) |
| References | 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 2. O'Brien AM, et al. Location of crosslinks in chemically stabilized horseradish peroxidase: implications for design of crosslinks. Biotechnol Bioeng. 2001;76(4):277-284. 3. Forde J, et al. Chemical modification and immobilisation of laccase from Trametes hirsuta and from Myceliophthora thermophila. Enzyme Microb Technol. 2010;46(6):430-437. |