| Description | EGFR-IN-57 (Compound 25a) is a potent, orally active inhibitor of EGFR tyrosine kinase (EGFR-TK) with an IC50 of 0.054 μM. Additionally, it exhibits inhibitory activity against VEGFR-2, CK2α, topoisomerase IIβ, and tubulin polymerization with respective IC50 values of 0.087, 0.171, 0.13, and 3.61 μM. The compound promotes cell cycle arrest at the G2/M and pre-G1 phases and induces apoptosis in cancer cells [1]. |
| molecular weight | 385.44 |
| Molecular formula | C22H15N3O2S |
| CAS | 2492382-37-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |