| Description | Epidermal Growth Factor Receptor Peptide Acetate (Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base)) exists on the cell surface and is activated by the binding of its specific ligands.EGFR belongs to the ErbB family of receptor tyrosine kinases (RTK). |
| In vitro | 该化学化合物的自磷酸化作用引发下游几种蛋白质的激活和信号传递，这些蛋白质通过它们自有的含磷酸酪氨酸结合SH2结构域与磷酸化的酪氨酸相结合。这些下游信号传递蛋白触发多条信号转导级联反应，主要是MAPK、Akt和JNK途径，进而促进DNA合成和细胞增殖。这类蛋白质调节细胞迁移、粘附和增殖等表型。受体的激活对于人体皮肤的先天免疫反应十分重要。 |
| Synonyms | EGF Receptor Peptide Acetate (96249-43-3 Free base), Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base) |
| molecular weight | 1436.52 |
| Molecular formula | C63H97N13O25 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 10 mg/mL (7.27 mM) DMSO: 133 mg/mL (96.62 mM) |
| References | 1. Yan. L, Beckman RA (October 2005). "Pharmacogenetics and pharmacogenomics in oncology therapeutic antibody development". BioTechniques 39 (4): 565–8. |