| Description | Efmitermant alfa (ACE-083), a follistatin-based fusion protein with localized action, functions as a muscle-promoting agent and is utilized in the study of muscle disorders [1] [2]. |
| In vitro | ACE-083 (0-60 nM) 表现出对肝素和细胞外基质的高度亲和性[1]。 |
| In vivo | ACE-083（肌肉注射；0-100 µg；每周两次，持续4周）在野生型及Charcot-Marie-Tooth (CMT)病和Duchenne肌营养不良症的小鼠模型上显示出引起注射处肌肉的局部、剂量依赖性肥大。此外，它还能提高野生型及疾病模型小鼠胫骨前肌的原位等长收缩力，并增强CMT小鼠模型的踝关节背屈扭矩。 |
| Synonyms | ACE083 |
| molecular weight | N/A |
| CAS | 1644543-31-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years | Shipping with blue ice. |