| Description | Edoxudine (Epoxudine), an antiviral drug, is an analogue of thymidine and shows effectiveness against the herpes simplex virus. Edoxudine is used as a 5-fluorouracil (FU) modulator. Edoxudine may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels. It can also enhance the antitumour action of 5-FU. |
| Synonyms | 依度尿苷, Aedurid, EUDR, Epoxudine, 乙去氧尿啶 |
| molecular weight | 256.26 |
| Molecular formula | C11H16N2O5 |
| CAS | 15176-29-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (175.6 mM) |
| References | 1. Kralovanszky, et al. 5-Ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil[J]. Journal of Cancer Research & Clinical Oncology, 1999, 125(12):675-684. 2. Jeney A, et al. 5-Ethyl-2'-deoxyuridine: an explanation for its lack of cytotoxic action in vivo[J]. European Journal of Cancer & Clinical Oncology, 1986, 22(5):557-562. |