| Description | Eclalbasaponin I has anti-oxidative, and antitumor activities, it reduces oxidative stress-induced neural cell death by autophagy activation, it can dose-dependently inhibit the proliferation of hepatoma cell smmc-7721 with the IC(50) value of 111.1703 ug/ml. |
| In vitro | 四个分馏物（水、30%乙醇、60%乙醇和90%乙醇）被获得。四种化合物，包括Wedelolactone（I）、Eclalbasaponin I（II）、木犀草素（III）和木犀草素-7-O-葡萄糖苷（IV）被纯化，并通过解释MS、(1)H和(13)C NMR等光谱分析鉴定了其结构。通过使用肝癌细胞smmc-7721作为体外检测系统，评估了提取物（总分馏物）、四个分馏物以及分离化合物的抗肿瘤活性。结果显示，30%乙醇分馏物和Eclalbasaponin I能剂量依赖性抑制肝癌细胞smmc-7721的增殖，其IC(50)值分别为74.2399 μg/ml和111.1703 μg/ml，与阳性对照组5-氟尿嘧啶的IC(50)值195.3131 μg/ml相比，具有更强的抑制作用。其他分馏物和化合物的抗肿瘤活性低于阳性对照。 |
| Target activity | Smmc 7721 cells:111.1703 μg/ml (IC50) |
| molecular weight | 796.98 |
| Molecular formula | C42H68O14 |
| CAS | 158511-59-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 27.5 mg/mL (34.51 mM) |
| References | 1. Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity.Food Chem Toxicol. 2012 Nov;50(11):4016-22. |