PeptideDB

E7107

CAS No.: 630100-90-2

E7107 is a first-in-class inhibitor of precursor messenger ribonucleic acid spliceosome.
Sales Email:peptidedb@qq.com

This product is for research use only, not for human use. We do not sell to patients.

Description E7107 is a first-in-class inhibitor of precursor messenger ribonucleic acid spliceosome.
Synonyms E-7107, E 7107
molecular weight 718.96
Molecular formula C40H66N2O9
CAS 630100-90-2
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Finci LI, Zhang X, Huang X, Zhou Q, Tsai J, Teng T, Agrawal A, Chan B, Irwin S, Karr C, Cook A, Zhu P, Reynolds D, Smith PG, Fekkes P, Buonamici S, Larsen NA. The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action. Genes Dev. 2018 Feb 1;32(3-4):309-320. doi: 10.1101/gad.311043.117. PubMed PMID: 29491137. 2. Núñez A, Núñez C, Corsi O, Rada G. Are cannabinoids effective for HIV wasting syndrome? Medwave. 2017 Dec 22;17(9):e7107. doi: 10.5867/medwave.2017.09.7107. Spanish, English. PubMed PMID: 29272264. 3. Chan S, Sridhar P, Kirchner R, Lock YJ, Herbert Z, Buonamici S, Smith P, Lieberman J, Petrocca F. Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival. Mol Cancer Ther. 2017 Dec;16(12):2849-2861. doi: 10.1158/1535-7163.MCT-17-0461. Epub 2017 Sep 6. PubMed PMID: 28878028. 4. Lee EP, Hsia SH, Huang JL, Lin JJ, Chan OW, Lin CY, Lin KL, Chang YC, Chou IJ, Lo FS, Lee J, Hsin YC, Chan PC, Hu MH, Chiu CH, Wu HP. Epidemiology and clinical analysis of critical patients with child maltreatment admitted to the intensive care units. Medicine (Baltimore). 2017 Jun;96(23):e7107. doi: 10.1097/MD.0000000000007107. PubMed PMID: 28591056; PubMed Central PMCID: PMC5466234.