| Description | E235 is a regulatory activator of transcription factor 4 (ATF4) with antiproliferative activity.E235 acts by initiating the integrated stress response (ISR) and signaling the DNA damage response. |
| In vitro | 在 HT1080、B16F10 和 AG1522 细胞中，E235（0、1、5和 10 µM；4小时）能够以剂量依赖性方式增加 ATF4 的表达[1]。 |
| Synonyms | E-235, E 235 |
| molecular weight | 484.59 |
| Molecular formula | C28H25FN4OS |
| CAS | 891894-69-2 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (Insoluble) DMSO: 5 mg/mL (10.31 mM), Sonication is recommended. |
| References | 1. Sayers CM, et al. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response. Mol Pharmacol. 2013 Mar;83(3):594-604. |