| Description | (E/Z)-Polydatin (Polydatin), is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. |
| In vitro | 在盲肠结扎穿孔诱导的败血症小鼠体内,Polydatin（15/45/100 mg/kg）可抑制CLP诱导的血清TNF-α和IL-6的产生、肺环氧合酶-2和诱导型NO合酶异构体的蛋白质表达及NF-κB活化,从而剂量依赖性降低败血症造成的死亡率和肺损伤.小鼠中Polydatin的LD50为1 g/kg（i.p.）. |
| In vivo | Polydatin是一种PLA2抑制剂,可使sPLA2-IIA mRNA表达和磷脂酶A2活性降低,还可使Clara细胞分泌蛋白的表达增加,从而减轻脂多糖诱导的肺部损伤。 |
| Synonyms | 云杉新甙, (E/Z)-虎杖苷, Polydatin, (E/Z)-Piceid |
| molecular weight | 390.38 |
| Molecular formula | C20H22O8 |
| CAS | 65914-17-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (115.27 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Shiyu S, et al. BMC Cell Biol, 2011, 25, 12:31. 2. Li XH, et al. Mediators Inflamm, 2013, 2013, 354087. |