| Description | DQn-1, a potent antifolate, demonstrates efficacy against Mycobacterium tuberculosis (Mtb) with an MIC 90 of 0.03 µM. It inhibits the DHFR enzyme, exhibiting IC 50 values of 8.7 nM for Mtb DHFR and 7.6 nM for the human counterpart [1]. |
| In vitro | DQn-1 对抗结核分枝杆菌具有抑制作用，其最小抑菌浓度（MIC 90）值为0.03 µM至1 µM [1]。 |
| In vivo | DQn-1（按5-10 mg/kg剂量，经口给药连续8天）在小鼠体内未观察到显著的Mtb负荷减少[1]。 |
| molecular weight | 343.77 |
| Molecular formula | C16H14ClN5O2 |
| CAS | 57343-54-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |